An Introduction and Facts for a Malaysian Study on Kratom’s Main Alkaloid


Introduction for the Study on Understanding the Physicochemical Properties of Mitragynine, a Principal Alkaloid of Mitragyna Speciosa, for Preclinical Evaluation

A study was done in Malaysia in 2015 concerning the physicochemical properties of the alkaloid known as Mitragynin. This alkaloid is the most dense and abundant in kratom, and it is what gives the natural drug its power. Specifically, it is an indole alkaloid.

Indole is a completely organic, aromatic compound. Chemically, it is sort of structured like a bike with two attached wheels with a different number of spokes. One of the chemical wheels in the alkaloid is a benzene wheel, which contains six members. The benzene wheel is fused to a pyrrole wheel, which is made up of five nitrogen spokes. Indole is widespread in the ecosystem, and a variety of bacteria are capable of producing it, which would explain why it is so prolific in the environment.

There are two interesting facts about the indole alkaloid related to the study and kratom as a subject in the author’s opinion. First off, it is one of the properties derived from tryptophan, which is an amino acid with physiological and cognitive benefits. The second fact might help explain a little why kratom is such a good mood booster, and it is because this alkaloid is a precursor or harbinger of the serotonin neurotransmitter. Serotonin is released naturally by the body, and it has a wide variety of functions, but it is also a tool for the brain. Serotonin is used in a number of psychoactive drugs, but it is also utilized heavily in psychiatry to elevate mood. Kratom has been described by many people as a mood booster.

Aside from the mood boosting effects of mitragynine, it has also been called a legal opioid, but few psychoactive property studies have been done to validate the claim. Kratom users experience the truth though. They document in forums constantly about kratom, which mitragynine is the main alkaloid contained in it, relieves pain and boosts mood. Some kratom users and patients treated with mitragynine have also reported a feeling of relaxation. There have also been reports of paradoxical effects because of a stimulant experience. The feeling of relaxation or stimulation typically depends on the color of the leaf’s vein and the dosage of kratom taken. White veined kratom leaves are known to stimulate, and green and red veined kratom leaves are known to relax.

The full study can be view at

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